Accidental intrathecal mercury application

Accidental intrathecal methotrexate overdose.

Re: Treatment of accidental intrathecal methotrexate overdose.

Widemann et al. (1) presented data on the use of cerebrospinal fl uid (CSF) exchange to remove methotrexate before carboxypeptidase G 2 (CPDG 2) administration among patients who had an accidental intrathecal methotrexate overdose. They reported that CSF drainage removed 32% – 58% of the methotrexate dose. Although they showed the percent decreases in CSF methotrexate concentration before and a...

Accidental intrathecal administration of high dose diamorphine.

A case of accidental administration of high dose intrathecal diamorphine is reported in a patient who underwent total knee replacement. Initially a regional technique was planned for this patient, but due to inadvertent administration of three milligrams of diamorphine intrathecally, it was decided to convert the patient to have a general anaesthetic. Postoperatively, she was monitored in high ...

Accidental Intrathecal Injection of Tranexamic Acid

Tranexamic acid (TXA) is a popular antifibrinolytic drug that is commonly used in patients with bleeding disorder. Major morbidities and mortalities have been reported following inadvertent intrathecal injection of TXA. In this paper, inadvertent intrathecal injection of TXA has resulted from similarities in appearance between TXA and heavy bupivacaine 0.5% ampoules. The patient experienced sev...

Neural toxicity induced by accidental intrathecal vincristine administration.

Described here is a case of accidental intrathecal administration of vincristine with pathologic findings in the central nervous system. A 3-year-old boy with acute lymphoblastic leukemia, was given his ninth course chemotherapy. Vincristine was accidentally injected intrathecally. The clinical course was rapidly progressive (6-day course) and resulted in death. An autopsy was done. The brain a...